In a Debian 12 Bookworm installation I faced several problems at bootstrap. Some services does not start basically because the /run hierarchy was not properly initialized with the required subdirectories. E.g. one OpenVPN service does not start beacuse the /run/openvpn/ directory does not exists:

ovpn-office[2853]: Options error: --writepid fails with '/run/openvpn/office.pid':
    No such file or directory (errno=2)

An enlightening error message is displayed by dmesg:

systemd[1]: sysinit.target: Found ordering cycle on systemd-tmpfiles-setup.service/start
systemd[1]: sysinit.target: Job systemd-tmpfiles-setup.service/start deleted to break
            ordering cycle starting with sysinit.target/start